LYMPHOID NEOPLASIA Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma
نویسندگان
چکیده
1Abteilung für Pathologie des Universitätklinikums Ulm, Ulm, Germany; 2Inserm, Unité U955, Créteil, France; 3Université Paris 12, Faculté de Médecine, Créteil, France; 4Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Necker, Service de Biostatistiques, Paris, France; 5Université Paris Descartes, Paris, France; and 6AP-HP, Groupe Hospitalier Henri-Mondor Albert-Chenevier, Département de Pathologie, Créteil, France
منابع مشابه
Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.
Primary mediastinal B-cell lymphoma (PMBL) is a separate entity of aggressive B-cell lymphoma, characterized by a constitutive activation of janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, also observed in Hodgkin lymphoma. Although many cancers exhibit constitutive JAK-STAT pathway activation, mutations of STAT genes have not been reported in neoplas...
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Primary mediastinal B-cell lymphoma (PMBL) is characterized by aberrant activation of JAK/STAT-signaling resulting in constitutive presence of phosphorylated STAT6 (pSTAT6). In primary PMBL samples pSTAT6 is only expressed in a sub-population of lymphoma cells in a pattern that is reminiscent of that of the BCL6 oncogene. Double-fluorescence staining was carried out to determine the association...
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Primary mediastinal large B-cell lymphoma (PMBL), currently recognized as a diffuse large B-cell lymphoma (DLBCL) subtype, shows increased expression of interleukin 4 (IL-4)/IL-13 signaling effectors and targets, suggesting constitutive activation of these pathways. We therefore investigated the functional state of the signal transducer and activator of transcription 6 (STAT6), mediating IL-4/I...
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Primary mediastinal B-cell lymphoma (PMBL) is a high grade B-cell lymphoma with distinct clinical and molecular features, which is confined to the mediastinum at presentation although relapsed disease can be more widespread. PMBL accounts for just 3 % of all nonHodgkin’s lymphomas and tends to present in young women. It is conventionally treated with combination chemotherapy, usually followed b...
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Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transformed FL case and expanded findings to a combined total of 114 FLs. We report r...
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تاریخ انتشار 2009